Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance.

The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to applications of these concepts is a lack of detail concerning how the environment...

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Bibliographic Details
Main Authors: C Brandon Ogbunugafor, C Scott Wylie, Ibrahim Diakite, Daniel M Weinreich, Daniel L Hartl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4726534?pdf=render