Widespread Recruitment of Ancient Domain Structures in Modern Enzymes during Metabolic Evolution
Protein domains sometime combine to form multidomain proteins and are acquired or lost in lineages of organisms. These processes are ubiquitous in modern metabolism. To sort out evolutionary patterns of domain recruitment, we developed an algorithm that derives the most plausible ancestry of an enzy...
Main Authors: | Kim Hee Shin, Mittenthal Jay E., Caetano-Anollés Gustavo |
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Format: | Article |
Language: | English |
Published: |
De Gruyter
2013-03-01
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Series: | Journal of Integrative Bioinformatics |
Online Access: | https://doi.org/10.2390/biecoll-jib-2013-214 |
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