Widespread Recruitment of Ancient Domain Structures in Modern Enzymes during Metabolic Evolution

Protein domains sometime combine to form multidomain proteins and are acquired or lost in lineages of organisms. These processes are ubiquitous in modern metabolism. To sort out evolutionary patterns of domain recruitment, we developed an algorithm that derives the most plausible ancestry of an enzy...

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Bibliographic Details
Main Authors: Kim Hee Shin, Mittenthal Jay E., Caetano-Anollés Gustavo
Format: Article
Language:English
Published: De Gruyter 2013-03-01
Series:Journal of Integrative Bioinformatics
Online Access:https://doi.org/10.2390/biecoll-jib-2013-214