Improved spatial memory, neurobehavioral outcomes, and neuroprotective effect after progesterone administration in ovariectomized rats with traumatic brain injury: Role of RU486 progesterone receptor antagonist

Improved spatial memory, neurobehavioral outcomes, and neuroprotective effect after progesterone administration in ovariectomized rats with traumatic brain injury: Role of RU486 progesterone receptor antagonist

Objective(s): The contribution of classic progesterone receptors (PR) in interceding the neuroprotective efficacy of progesterone (P4) on the prevention of brain edema and long-time behavioral disturbances was assessed in traumatic brain injury (TBI). Materials and Methods: Female Wistar rats were o...

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Bibliographic Details
Main Authors: Ladan Amirkhosravi, Mohammad Khaksari, Vahid Sheibani, Nader Shahrokhi, Mohammad navid Ebrahimi, Sedigheh Amiresmaili, Neda Salmani
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2021-03-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
behavioral disorders
mifepristone
neuroprotection
progesterone
spatial memory
tbi
Online Access:https://ijbms.mums.ac.ir/article_17461_aa211a998b5641288b9f79a275600712.pdf

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https://ijbms.mums.ac.ir/article_17461_aa211a998b5641288b9f79a275600712.pdf

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