Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
Cellular models of organs have been used to investigate mechanisms of disease. Here the authors generate a human alpha synuclein-induced brain-chip model that recapitulates blood-brain barrier dysfunction, as a potential testing platform for novel therapeutics in Parkinson’s disease.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26066-5 |
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doaj-4c79c98786c94d82a820ab3e121c9759 |
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doaj-4c79c98786c94d82a820ab3e121c97592021-10-10T11:44:37ZengNature Publishing GroupNature Communications2041-17232021-10-0112111710.1038/s41467-021-26066-5Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruptionIosif Pediaditakis0Konstantia R. Kodella1Dimitris V. Manatakis2Christopher Y. Le3Chris D. Hinojosa4William Tien-Street5Elias S. Manolakos6Kostas Vekrellis7Geraldine A. Hamilton8Lorna Ewart9Lee L. Rubin10Katia Karalis11Emulate Inc., 27 Drydock AvenueEmulate Inc., 27 Drydock AvenueEmulate Inc., 27 Drydock AvenueEmulate Inc., 27 Drydock AvenueEmulate Inc., 27 Drydock AvenueEmulate Inc., 27 Drydock AvenueDepartment of Informatics and Telecommunications, National and Kapodistrian University of AthensBiomedical Research Foundation of Academy of AthensEmulate Inc., 27 Drydock AvenueEmulate Inc., 27 Drydock AvenueDepartment of Stem Cell and Regenerative Biology, Harvard UniversityEmulate Inc., 27 Drydock AvenueCellular models of organs have been used to investigate mechanisms of disease. Here the authors generate a human alpha synuclein-induced brain-chip model that recapitulates blood-brain barrier dysfunction, as a potential testing platform for novel therapeutics in Parkinson’s disease.https://doi.org/10.1038/s41467-021-26066-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Iosif Pediaditakis Konstantia R. Kodella Dimitris V. Manatakis Christopher Y. Le Chris D. Hinojosa William Tien-Street Elias S. Manolakos Kostas Vekrellis Geraldine A. Hamilton Lorna Ewart Lee L. Rubin Katia Karalis |
| spellingShingle |
Iosif Pediaditakis Konstantia R. Kodella Dimitris V. Manatakis Christopher Y. Le Chris D. Hinojosa William Tien-Street Elias S. Manolakos Kostas Vekrellis Geraldine A. Hamilton Lorna Ewart Lee L. Rubin Katia Karalis Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption Nature Communications |
| author_facet |
Iosif Pediaditakis Konstantia R. Kodella Dimitris V. Manatakis Christopher Y. Le Chris D. Hinojosa William Tien-Street Elias S. Manolakos Kostas Vekrellis Geraldine A. Hamilton Lorna Ewart Lee L. Rubin Katia Karalis |
| author_sort |
Iosif Pediaditakis |
| title |
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption |
| title_short |
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption |
| title_full |
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption |
| title_fullStr |
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption |
| title_full_unstemmed |
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption |
| title_sort |
modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-10-01 |
| description |
Cellular models of organs have been used to investigate mechanisms of disease. Here the authors generate a human alpha synuclein-induced brain-chip model that recapitulates blood-brain barrier dysfunction, as a potential testing platform for novel therapeutics in Parkinson’s disease. |
| url |
https://doi.org/10.1038/s41467-021-26066-5 |
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