Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

Cellular models of organs have been used to investigate mechanisms of disease. Here the authors generate a human alpha synuclein-induced brain-chip model that recapitulates blood-brain barrier dysfunction, as a potential testing platform for novel therapeutics in Parkinson’s disease.

Bibliographic Details
Main Authors: Iosif Pediaditakis, Konstantia R. Kodella, Dimitris V. Manatakis, Christopher Y. Le, Chris D. Hinojosa, William Tien-Street, Elias S. Manolakos, Kostas Vekrellis, Geraldine A. Hamilton, Lorna Ewart, Lee L. Rubin, Katia Karalis
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26066-5

Internet

https://doi.org/10.1038/s41467-021-26066-5

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