Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
Cellular models of organs have been used to investigate mechanisms of disease. Here the authors generate a human alpha synuclein-induced brain-chip model that recapitulates blood-brain barrier dysfunction, as a potential testing platform for novel therapeutics in Parkinson’s disease.
Bibliographic Details
| Main Authors: |
Iosif Pediaditakis,
Konstantia R. Kodella,
Dimitris V. Manatakis,
Christopher Y. Le,
Chris D. Hinojosa,
William Tien-Street,
Elias S. Manolakos,
Kostas Vekrellis,
Geraldine A. Hamilton,
Lorna Ewart,
Lee L. Rubin,
Katia Karalis |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-26066-5
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