The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF

Abstract Background C-X-C chemokine ligand 13 (CXCL13) is frequently elevated in cerebrospinal fluid (CSF) in a variety of inflammatory central nervous system (CNS) diseases, has been detected in meningeal B cell aggregates in brain tissues of multiple sclerosis patients, and proposedly recruits B c...

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Bibliographic Details
Main Authors: Christine Harrer, Ferdinand Otto, Georg Pilz, Elisabeth Haschke-Becher, Eugen Trinka, Wolfgang Hitzl, Peter Wipfler, Andrea Harrer
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Fluids and Barriers of the CNS
Subjects:
CSF
CNS
Online Access:https://doi.org/10.1186/s12987-021-00272-1