Modeling and live imaging of mechanical instabilities in the zebrafish aorta during hematopoiesis

Abstract All blood cells originate from hematopoietic stem/progenitor cells (HSPCs). HSPCs are formed from endothelial cells (ECs) of the dorsal aorta (DA), via endothelial-to-hematopoietic transition (EHT). The zebrafish is a primary model organism to study the process in vivo. While the role of me...

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Bibliographic Details
Main Authors: Dmitrii Chalin, Charlotte Bureau, Andrea Parmeggiani, Sergei Rochal, Karima Kissa, Ivan Golushko
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88667-w