Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry – a prospectively controlled randomized double-blind clinical trial

Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry – a prospectively controlled randomized double-blind clinical trial

Abstract Background Argatroban or lepirudin anticoagulation therapy in patients with heparin induced thrombocytopenia (HIT) or HIT suspect is typically monitored using the activated partial thromboplastin time (aPTT). Although aPTT correlates well with plasma levels of argatroban and lepirudin in he...

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Bibliographic Details
Main Authors: Martin Beiderlinden, Patrick Werner, Astrid Bahlmann, Johann Kemper, Tobias Brezina, Maximilian Schäfer, Klaus Görlinger, Holger Seidel, Peter Kienbaum, Tanja A. Treschan
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Anesthesiology
Subjects:
Heparin-induced thrombocytopenia
Rotational thromboelastometry
Argatroban
Lepirudin
Monitoring
Maximum clot firmness
Online Access:http://link.springer.com/article/10.1186/s12871-018-0475-y

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http://link.springer.com/article/10.1186/s12871-018-0475-y

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