Comprehensive high-throughput meta-analysis of differentially expressed microRNAs in transcriptomic datasets reveals significant disruption of MAPK/JNK signal transduction pathway in Adult T-cell leukemia/lymphoma

Comprehensive high-throughput meta-analysis of differentially expressed microRNAs in transcriptomic datasets reveals significant disruption of MAPK/JNK signal transduction pathway in Adult T-cell leukemia/lymphoma

Abstract Background Human T-lymphotropic virus 1 (HTLV-1) infection may lead to the development of Adult T-cell leukemia/lymphoma (ATLL). To further elucidate the pathophysiology of this aggressive CD4+ T-cell malignancy, we have performed an integrated systems biology approach to analyze previous t...

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Main Authors: Shahrzad Shadabi, Nargess Delrish, Mehdi Norouzi, Maryam Ehteshami, Fariba Habibian-Sezavar, Samira Pourrezaei, Mobina Madihi, Mohammadreza Ostadali, Foruhar Akhgar, Ali Shayeghpour, Cobra Razavi Pashabayg, Sepehr Aghajanian, Sayed-Hamidreza Mozhgani, Seyed-Mohammad Jazayeri
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Infectious Agents and Cancer
Subjects:
HTLV-1
Adult T-cell leukemia/lymphoma
Systems biology
Gene expression analysis
JNK pathway
Online Access:https://doi.org/10.1186/s13027-021-00390-3

Internet

https://doi.org/10.1186/s13027-021-00390-3

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