Inhibition of caspase-8 activity reduces IFN-gamma expression by T cells from Leishmania major infection

Inhibition of caspase-8 activity reduces IFN-gamma expression by T cells from Leishmania major infection

Following infection with Leishmania major, T cell activation and apoptosis can be detected in draining lymph nodes of C57BL/6-infected mice. We investigated the mechanisms involved in apoptosis and cytokine expression following Tcellactivation. After two weeks of infection, apoptotic T cells were no...

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Bibliographic Details
Main Authors: Wânia F. Pereira, Landi V.C. Guillermo, Flávia L. Ribeiro-Gomes, Marcela F. Lopes
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2008-03-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
apoptose
caspase-8
células T CD8
IFN-gama
Leishmanioses
apoptosis
CD8 T cells
IFN-gamma
Leishmaniasis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100008

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