Comprehensive Genetic Analysis of a Hungarian Amyotrophic Lateral Sclerosis Cohort

Comprehensive Genetic Analysis of a Hungarian Amyotrophic Lateral Sclerosis Cohort

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration of motor neurons. Genetic factors play a key role in ALS, and identifying variants that contribute to ALS susceptibility is an important step toward understanding the etiology of the dise...

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Bibliographic Details
Main Authors: Kornélia Tripolszki, Piyush Gampawar, Helena Schmidt, Zsófia F. Nagy, Dóra Nagy, Péter Klivényi, József I. Engelhardt, Márta Széll
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Genetics
Subjects:
amyotrophic lateral sclerosis
oligogenic inheritance
next-generation sequencing
mutation screening
C9orf72 repeat expansion
genetic heterogeneity
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00732/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00732/full

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