Neuromuscular Junction Changes in a Mouse Model of Charcot-Marie-Tooth Disease Type 4C

Neuromuscular Junction Changes in a Mouse Model of Charcot-Marie-Tooth Disease Type 4C

The neuromuscular junction (NMJ) appears to be a site of pathology in a number of peripheral nerve diseases. Charcot-Marie-Tooth (CMT) 4C is an autosomal recessive, early onset, demyelinating neuropathy. Numerous mutations in the <i>SH3TC2</i> gene have been shown to underlie the conditi...

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Bibliographic Details
Main Authors: Silvia Cipriani, Vietxuan Phan, Jean-Jacques Médard, Rita Horvath, Hanns Lochmüller, Roman Chrast, Andreas Roos, Sally Spendiff
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
Charcot-Marie-Tooth disease 4C
SH3TC2
neuromuscular junction
mouse models
peripheral neuropathy
demyelination
Online Access:https://www.mdpi.com/1422-0067/19/12/4072

Internet

https://www.mdpi.com/1422-0067/19/12/4072

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