Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes

Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes

Mitochondria harbor a unique fatty acid synthesis pathway (mtFAS) with mysterious functions gaining increasing interest, while its involvement in metabolic regulation is essentially unknown. Here we show that 3-Hydroxyacyl-ACP dehydratase (HTD2), a key enzyme in mtFAS pathway was primarily downregul...

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Bibliographic Details
Main Authors: Mengqi Zeng, Jie Xu, Zhengyi Zhang, Xuan Zou, Xueqiang Wang, Ke Cao, Weiqiang Lv, Yuting Cui, Jiangang Long, Zhihui Feng, Jiankang Liu
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Redox Biology
Subjects:
Mitochondrial fatty acid synthesis (mtFAS)
3-Hydroxyacyl-ACP dehydratase (HTD2)
Mitochondrial dysfunction
Oxidative stress
Insulin resistance
Lipoic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000963

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http://www.sciencedirect.com/science/article/pii/S2213231721000963

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