INFLUENCE OF POMEGRANATE JUICE ON THE CYP3A4-MEDIATED METABOLISM AND P-GLYCOPROTEIN MEDIATED TRANSPORT OF SAQUINAVIR IN VIVO AND EX VIVO MODELS

INFLUENCE OF POMEGRANATE JUICE ON THE CYP3A4-MEDIATED METABOLISM AND P-GLYCOPROTEIN MEDIATED TRANSPORT OF SAQUINAVIR IN VIVO AND EX VIVO MODELS

Cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) play an important role in the first pass metabolism thereby limits the oral bioavailability of many clinically important and frequently prescribed drugs. The absolute oral bioavailability of saquinavir is very low (i. e. 4%) due to its extensive...

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Bibliographic Details
Main Authors: Sridhar Vemulapalli, Surya Sandeep Mullapudi, Ravindrababu Pingili, Ramya Kothapalli, Sivaramakrishna Kondru, Naveenbabu Kilaru
Format: Article
Language:English
Published: Universitas Gadjah Mada 2016-07-01
Series:Indonesian Journal of Pharmacy
Subjects:
CYP3A4
P-glycoprotein
Everted gut sacs
Pomegranate juice
Pharmacokinetics
Online Access:http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1090

Internet

http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1090

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