Rosmarinic acid protects against hypertensive nephropathy by inhibiting NADPH oxidase/ROS/NLRP3 inflammasome pathway

Rosmarinic acid protects against hypertensive nephropathy by inhibiting NADPH oxidase/ROS/NLRP3 inflammasome pathway

Objective To investigate the protective effect of rosmarinic acid (RA) on hypertensive nephropathy in mice and its underlying mechanism. Methods Thirty male C57BL/6 mice (6~8 weeks) were randomly divided into 3 groups: control group, AngⅡ group (Angiotensin II, 1.46 mg·kg-1·d-1) and AngⅡ+RA group (A...

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Bibliographic Details
Main Authors: CHEN Ruidan, ZHANG Yan, YANG Peili, LI Fangtang, CHEN Ken, YANG Yongjian
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2021-06-01
Series:Di-san junyi daxue xuebao
Subjects:
rosmarinic acid
hypertensive nephropathy
nlrp3 inflammasome
nadph oxidase
reactive oxygen species
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/202012049.htm

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http://aammt.tmmu.edu.cn/Upload/rhtml/202012049.htm

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