Unexpected Transcriptional Programs Contribute to Hippocampal Memory Deficits and Neuronal Stunting after Early-Life Adversity

Unexpected Transcriptional Programs Contribute to Hippocampal Memory Deficits and Neuronal Stunting after Early-Life Adversity

Summary: Early-life adversity (ELA) is associated with lifelong memory deficits, yet the responsible mechanisms remain unclear. We impose ELA by rearing rat pups in simulated poverty, assess hippocampal memory, and probe changes in gene expression, their transcriptional regulation, and the consequen...

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Bibliographic Details
Main Authors: Jessica L. Bolton, Anton Schulmann, Megan M. Garcia-Curran, Limor Regev, Yuncai Chen, Noriko Kamei, Manlin Shao, Akanksha Singh-Taylor, Shan Jiang, Yoav Noam, Jenny Molet, Ali Mortazavi, Tallie Z. Baram
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
NRSF
REST
early-life stress
memory
hippocampus
neuronal development
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031500X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472031500X

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