Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Abstract Background Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development. Although it is known that maternal folate deficiency increases the risk of NTDs, the mechanism remains elusive. Results Herein, we re...

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Bibliographic Details
Main Authors: Pei Pei, Xiyue cheng, Juan Yu, Jinying Shen, Xue Li, Jianxin Wu, Shan Wang, Ting Zhang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Epigenetics & Chromatin
Subjects:
Neural tube defect
Histone ubiquitination
Folate antagonist methotrexate
Mouse double minute 2 homolog (Mdm2, MDM2)
Neural tube closure-related genes
Online Access:http://link.springer.com/article/10.1186/s13072-019-0312-7

Internet

http://link.springer.com/article/10.1186/s13072-019-0312-7

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