Combinatorial Pharmacophore-Based 3D-QSAR Analysis and Virtual Screening of FGFR1 Inhibitors

Combinatorial Pharmacophore-Based 3D-QSAR Analysis and Virtual Screening of FGFR1 Inhibitors

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling pathway plays crucial roles in cell proliferation, angiogenesis, migration, and survival. Aberration in FGFRs correlates with several malignancies and disorders. FGFRs have proved to be attractive targets for therape...

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Bibliographic Details
Main Authors: Nannan Zhou, Yuan Xu, Xian Liu, Yulan Wang, Jianlong Peng, Xiaomin Luo, Mingyue Zheng, Kaixian Chen, Hualiang Jiang
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:International Journal of Molecular Sciences
Subjects:
pharmacophore
combinatorial 3D-QSAR
virtual screening
FGFR1 inhibitors
Online Access:http://www.mdpi.com/1422-0067/16/6/13407

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http://www.mdpi.com/1422-0067/16/6/13407

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