Enhanced antitumor effects of follicle-stimulating hormone receptor-mediated hexokinase-2 depletion on ovarian cancer mediated by a shift in glucose metabolism

Enhanced antitumor effects of follicle-stimulating hormone receptor-mediated hexokinase-2 depletion on ovarian cancer mediated by a shift in glucose metabolism

Abstract Background Most cancers favor glycolytic-based glucose metabolism. Hexokinase-2 (HK2), the first glycolytic rate-limiting enzyme, shows limited expression in normal adult tissues but is overexpressed in many tumor tissues, including ovarian cancer. HK2 has been shown to be correlated with t...

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Bibliographic Details
Main Authors: Meng Zhang, Qiyu Liu, Mingxing Zhang, Cong Cao, Xiaoxia Liu, Mengyu Zhang, Guiling Li, Congjian Xu, Xiaoyan Zhang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Nanobiotechnology
Subjects:
Ovarian carcinoma
Hexokinase-2
Targeted therapy
Chemoresistance
Follicle-stimulating hormone
Online Access:http://link.springer.com/article/10.1186/s12951-020-00720-4

Internet

http://link.springer.com/article/10.1186/s12951-020-00720-4

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