T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance

T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance

Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal women. Under chronic inflammatory conditions caused by estrogen deficiency, activated T cells contribute to elevated levels of proinflammatory cytokines, impaired osteogenic differentiation capabilities of bone...

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Bibliographic Details
Main Authors: Xiaoshan Yang, Fuxing Zhou, Pingyun Yuan, Geng Dou, Xuemei Liu, Siying Liu, Xiangdong Wang, Ronghua Jin, Yan Dong, Jun Zhou, Yajie Lv, Zhihong Deng, Shiyu Liu, Xin Chen, Ying Han, Yan Jin
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-10-01
Series:Bioactive Materials
Subjects:
Nanoparticles
Activated T cell
Immune tolerance
Apoptotic extracellular vesicles
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21000943

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X21000943

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