A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex
Intrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass. Here, the authors reconstitute the selective behaviour of the NPC by introducing a rationally...
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| Format: | Article |
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22293-y |
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doaj-4be48fd698744ead86133548fa049b92 |
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doaj-4be48fd698744ead86133548fa049b922021-04-04T11:12:57ZengNature Publishing GroupNature Communications2041-17232021-03-0112111510.1038/s41467-021-22293-yA designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complexAlessio Fragasso0Hendrik W. de Vries1John Andersson2Eli O. van der Sluis3Erik van der Giessen4Andreas Dahlin5Patrick R. Onck6Cees Dekker7Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyZernike Institute for Advanced Materials, University of GroningenDepartment of Chemistry and Chemical Engineering, Chalmers University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyZernike Institute for Advanced Materials, University of GroningenDepartment of Chemistry and Chemical Engineering, Chalmers University of TechnologyZernike Institute for Advanced Materials, University of GroningenDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyIntrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass. Here, the authors reconstitute the selective behaviour of the NPC by introducing a rationally designed artificial FG-Nup that demonstrates that no specific spacer sequence nor a spatial segregation of different FG-motif types are needed to create selective NPCs.https://doi.org/10.1038/s41467-021-22293-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alessio Fragasso Hendrik W. de Vries John Andersson Eli O. van der Sluis Erik van der Giessen Andreas Dahlin Patrick R. Onck Cees Dekker |
| spellingShingle |
Alessio Fragasso Hendrik W. de Vries John Andersson Eli O. van der Sluis Erik van der Giessen Andreas Dahlin Patrick R. Onck Cees Dekker A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex Nature Communications |
| author_facet |
Alessio Fragasso Hendrik W. de Vries John Andersson Eli O. van der Sluis Erik van der Giessen Andreas Dahlin Patrick R. Onck Cees Dekker |
| author_sort |
Alessio Fragasso |
| title |
A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex |
| title_short |
A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex |
| title_full |
A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex |
| title_fullStr |
A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex |
| title_full_unstemmed |
A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex |
| title_sort |
designer fg-nup that reconstitutes the selective transport barrier of the nuclear pore complex |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
Intrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass. Here, the authors reconstitute the selective behaviour of the NPC by introducing a rationally designed artificial FG-Nup that demonstrates that no specific spacer sequence nor a spatial segregation of different FG-motif types are needed to create selective NPCs. |
| url |
https://doi.org/10.1038/s41467-021-22293-y |
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