Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses.

Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses.

A major determinant in the change of the avian influenza virus host range to humans is the E627K substitution in the PB2 polymerase protein. However, the polymerase activity of avian influenza viruses with a single PB2-E627K mutation is still lower than that of seasonal human influenza viruses, impl...

Full description

Bibliographic Details
Main Authors: Yasuha Arai, Norihito Kawashita, Tomo Daidoji, Madiha S Ibrahim, Emad M El-Gendy, Tatsuya Takagi, Kazuo Takahashi, Yasuo Suzuki, Kazuyoshi Ikuta, Takaaki Nakaya, Tatsuo Shioda, Yohei Watanabe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4838241?pdf=render

Internet

http://europepmc.org/articles/PMC4838241?pdf=render

Similar Items