Inactivating the mannose-ethanolamine phosphotransferase Gpi7 confers caspofungin resistance in the human fungal pathogen Candida albicans

Understanding the molecular mechanisms governing antifungal resistance is crucial for identifying new cellular targets for developing new antifungal therapeutics. In this study, we performed a transposon-mediated genome-wide genetic screen in haploid Candida albicans to identify mutants resistant to...

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Bibliographic Details
Main Authors: Guisheng Zeng, Xiaoli Xu, Jiaxin Gao, Alessandra da Silva Dantas, Neil A.R. Gow, Yue Wang
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:The Cell Surface
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2468233021000104