Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites

Unique and essential aspects of parasite metabolism are excellent targets for development of new antimalarials. An improved understanding of parasite metabolism and drug resistance mechanisms is urgently needed. The antibiotic fosmidomycin targets the synthesis of essential isoprenoid compounds from...

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Bibliographic Details
Main Authors: Ann M. Guggisberg, Philip M. Frasse, Andrew J. Jezewski, Natasha M. Kafai, Aakash Y. Gandhi, Samuel J. Erlinger, Audrey R. Odom John
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.01193-18