Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity

Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity

Base editors can induce transcriptome-wide RNA off-target editing independent of gRNA. Here, the authors engineer ABEmax variants with minimized RNA off-target activities.

Bibliographic Details
Main Authors: Jianan Li, Wenxia Yu, Shisheng Huang, Susu Wu, Liping Li, Jiankui Zhou, Yu Cao, Xingxu Huang, Yunbo Qiao
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22519-z

Internet

https://doi.org/10.1038/s41467-021-22519-z

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