Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin.

Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin.

Mutations in the RHO gene encoding for the visual pigment protein, rhodopsin, are among the most common cause of autosomal dominant retinitis pigmentosa (ADRP). Previous studies of ADRP mutations in different domains of rhodopsin have indicated that changes that lead to more instability in rhodopsin...

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Bibliographic Details
Main Authors: James Mitchell, Fernanda Balem, Kalyan Tirupula, David Man, Harpreet Kaur Dhiman, Naveena Yanamala, Julian Ollesch, Joan Planas-Iglesias, Barbara J Jennings, Klaus Gerwert, Alessandro Iannaccone, Judith Klein-Seetharaman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0214639

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https://doi.org/10.1371/journal.pone.0214639

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