miR-29b-3p regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically stimulated osteocytes

miR-29b-3p regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically stimulated osteocytes

Abstract Background Mechanical loading is an essential factor for bone formation. A previous study indicated that mechanical tensile strain of 2500 microstrain (με) at 0.5 Hz for 8 h promoted osteogenesis and corresponding mechanoresponsive microRNAs (miRs) were identified in osteoblasts. However, i...

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Bibliographic Details
Main Authors: Qiangcheng Zeng, Yang Wang, Jie Gao, Zhixiong Yan, Zhenghua Li, Xianqiong Zou, Yanan Li, Jiahui Wang, Yong Guo
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
Mechanical tensile strain
Osteocyte
Osteoblast differentiation
miRNA microarray
Online Access:http://link.springer.com/article/10.1186/s11658-019-0136-2

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http://link.springer.com/article/10.1186/s11658-019-0136-2

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