Murine CD4<sup>+</sup>CD25<sup>-</sup> cells activated <it>in vitro</it> with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis <it>in vivo</it>

Murine CD4<sup>+</sup>CD25<sup>-</sup> cells activated <it>in vitro</it> with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis <it>in vivo</it>

<p>Abstract</p> <p>Background</p> <p>Induced regulatory T (iTreg) lymphocytes show promise for application in the treatment of allergic, autoimmune and inflammatory disorders. iTreg cells demonstrate advantages over natural Treg (nTreg) cells in terms of increased numbe...

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Bibliographic Details
Main Authors: Majowicz Anna, van der Marel Sander, te Velde Anje A, Meijer Sybren L, Petry Harald, van Deventer Sander J, Ferreira Valerie
Format: Article
Language:English
Published: BMC 2012-12-01
Series:BMC Gastroenterology
Subjects:
IBD
CD45RB transfer
Treg
PMA/ionomycin
Online Access:http://www.biomedcentral.com/1471-230X/12/172

Internet

http://www.biomedcentral.com/1471-230X/12/172

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