The Impact of Tumor Heterogeneity on Diagnostics and Novel Therapeutic Strategies in Multiple Myeloma

The Impact of Tumor Heterogeneity on Diagnostics and Novel Therapeutic Strategies in Multiple Myeloma

Myeloma is characterized by extensive inter-patient genomic heterogeneity due to multiple different initiating events. A recent multi-region sequencing study demonstrated spatial differences, with progression events, such as TP53 mutations, frequently being restricted to focal lesions. In this revie...

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Bibliographic Details
Main Authors: Leo Rasche, K. Martin Kortüm, Marc S. Raab, Niels Weinhold
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
multiple myeloma
spatial heterogeneity
risk stratification
minimal residual disease
targeted therapy
clinical imaging
immunotherapy
daratumumab
Online Access:http://www.mdpi.com/1422-0067/20/5/1248

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http://www.mdpi.com/1422-0067/20/5/1248

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