Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells.

Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells.

BACKGROUND:The adipocyte-derived hormone leptin influences the behaviour of a wide range of cell types and is now recognised as a pro-angiogenic and pro-inflammatory factor. In the vasculature, these effects are mediated in part through its direct leptin receptor (ObRb)-driven actions on endothelial...

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Bibliographic Details
Main Authors: Elena Garonna, Kathleen M Botham, Graeme M Birdsey, Anna M Randi, Ruben R Gonzalez-Perez, Caroline P D Wheeler-Jones
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3078934?pdf=render

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http://europepmc.org/articles/PMC3078934?pdf=render

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