Protective Effect of Minocycline against Ketamine-induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 beta Pathway

Protective Effect of Minocycline against Ketamine-induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 beta Pathway

AbstractIt has been suggested that ketamine cause injury during developing brain. Minocycline could prevent neuronal cell death through the activation of cell survival signals and the inhibition of apoptotic signals in models of neurodegenerative diseases. Here we investigated the protective effect...

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Bibliographic Details
Main Authors: Yang Lu, Shan Lei, Ning Wang, Pan Lu, Weisong Li, Juan Zheng, Praveen Giri, Haixia Lu, Xinlin Chen, Yong Liu, Pengbo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Ketamine
Minocycline
Neural Stem Cells
Akt
caspase-3
GSK-3β
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00135/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00135/full

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