Analyzing effect of quadruple multiple sequence alignments on deep learning based protein inter-residue distance prediction

Abstract Protein 3D structure prediction has advanced significantly in recent years due to improving contact prediction accuracy. This improvement has been largely due to deep learning approaches that predict inter-residue contacts and, more recently, distances using multiple sequence alignments (MS...

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Bibliographic Details
Main Authors: Aashish Jain, Genki Terashi, Yuki Kagaya, Sai Raghavendra Maddhuri Venkata Subramaniya, Charles Christoffer, Daisuke Kihara
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-87204-z