Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1

Plasmodium falciparum virulence is associated with sequestration of infected erythrocytes. Microvascular binding mediated by PfEMP1 in complex with non-immune immunoglobulin M (IgM) is common among parasites that cause both severe childhood malaria and pregnancy-associated malaria. Here, we present...

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Bibliographic Details
Main Authors: Reetesh Raj Akhouri, Suchi Goel, Hirotoshi Furusho, Ulf Skoglund, Mats Wahlgren
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715015211