Species-Specific Regulation of TRPM2 by PI(4,5)P<sub>2</sub> via the Membrane Interfacial Cavity

Species-Specific Regulation of TRPM2 by PI(4,5)P<sub>2</sub> via the Membrane Interfacial Cavity

The human apoptosis channel TRPM2 is stimulated by intracellular ADR-ribose and calcium. Recent studies show pronounced species-specific activation mechanisms. Our aim was to analyse the functional effect of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P<sub>2</sub>), commonly referred...

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Bibliographic Details
Main Authors: Daniel Barth, Andreas Lückhoff, Frank J. P. Kühn
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
TRPM2
PIP2
phospholipid
phosphoinositides
patch clamp
Online Access:https://www.mdpi.com/1422-0067/22/9/4637

Internet

https://www.mdpi.com/1422-0067/22/9/4637

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