Inhibition of Sonic Hedgehog Signaling Pathway by Thiazole Antibiotic Thiostrepton Attenuates the CD44+/CD24-Stem-Like Population and Sphere-Forming Capacity in Triple-Negative Breast Cancer

Inhibition of Sonic Hedgehog Signaling Pathway by Thiazole Antibiotic Thiostrepton Attenuates the CD44+/CD24-Stem-Like Population and Sphere-Forming Capacity in Triple-Negative Breast Cancer

Background/Aim: Triple-negative breast cancer (TNBC) represents a particular clinical challenge because these cancers do not respond to endocrine therapy or other available targeted agents. The lack of effective agents and obvious targets are major challenges in treating TNBC. In this study we explo...

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Bibliographic Details
Main Authors: Na Yang, Tai-Cheng Zhou, Xiu-xia Lei, Chang Wang, Min Yan, Zi-Feng Wang, Wei Liu, Jian Wang, Kai-Hua Ming, Bi-Cheng Wang, Bang-Lao Xu, Quentin Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Thiostrepton
Triple-negative breast cancer
Sonic hedgehog
Breast cancer stem cell
Online Access:http://www.karger.com/Article/FullText/443066

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http://www.karger.com/Article/FullText/443066

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