Early Microglial Activation Following Closed-Head Concussive Injury Is Dominated by Pro-Inflammatory M-1 Type

Early Microglial Activation Following Closed-Head Concussive Injury Is Dominated by Pro-Inflammatory M-1 Type

Microglial activation is a pathological hallmark of traumatic brain injury (TBI). Following brain injury, activated microglia/macrophages adopt different phenotypes, generally categorized as M-1, or classically activated, and M-2, or alternatively activated. While the M-1, or pro-inflammatory phenot...

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Bibliographic Details
Main Authors: Sindhu K. Madathil, Bernard S. Wilfred, Sarah E. Urankar, Weihong Yang, Lai Yee Leung, Janice S. Gilsdorf, Deborah A. Shear
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Neurology
Subjects:
microglia
inflammation
polarization
concussion
traumatic brain injury
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00964/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00964/full

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