Thyroid Hormone Induces PGC-1α during Dendritic Outgrowth in Mouse Cerebellar Purkinje Cells

Thyroid Hormone Induces PGC-1α during Dendritic Outgrowth in Mouse Cerebellar Purkinje Cells

Thyroid hormone 3,3′,5-Triiodo-L-thyronine (T3) is essential for proper brain development. Perinatal loss of T3 causes severe growth defects in neurons and glia, including strong inhibition of dendrite formation in Purkinje cells in the cerebellar cortex. Here we show that T3 promotes dendritic outg...

Full description

Bibliographic Details
Main Authors: Tetsu Hatsukano, Junko Kurisu, Kansai Fukumitsu, Kazuto Fujishima, Mineko Kengaku
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Purkinje cell
thyroid hormone
PGC-1α
mitochondria
dendritogenesis
hypothyroid
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00133/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00133/full

Similar Items