The Impact of Amorphisation and Spheronization Techniques on the Improved in Vitro & in Vivo Performance of Glimepiride Tablets

The Impact of Amorphisation and Spheronization Techniques on the Improved in Vitro & in Vivo Performance of Glimepiride Tablets

Purpose: Triple solid dispersion adsorbates (TSDads) and spherical agglomerates (SA) present new techniques that extensively enhance dissolution of poorly soluble drugs. The aim of the present study is to hasten the onset of hypoglycemic effect of glimepiride through enhancing its rate of release fr...

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Bibliographic Details
Main Authors: Rana Refaat Makar, Randa Latif, Ehab Ahmed Hosni, Omaima Naim El Gazayerly
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2017-12-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Dissolution
Pharmacodynamic study
Blood glucose level
Matrix tablets
Spherical agglomeration
Triple solid dispersion adsorbate
Online Access:http://apb.tbzmed.ac.ir/PDF/apb-7-557.pdf

Internet

http://apb.tbzmed.ac.ir/PDF/apb-7-557.pdf

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