Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS

Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS

Mitochondrial dysfunction is one of the converging paths for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and TDP-43 pathology is the most common proteinopathy detected in ALS and ALS/Frontotemporal lobar degeneration (ALS/FTLD). We recently identified mitochondria...

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Bibliographic Details
Main Authors: Mukesh Gautam, Edward F. Xie, Nuran Kocak, P. Hande Ozdinler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CSMN
electron microscopy
ALS
mouse models
mitochondria
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00489/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00489/full

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