MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis.In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for...

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Bibliographic Details
Main Authors: Elena Favaro, Anassuya Ramachandran, Robert McCormick, Harriet Gee, Christine Blancher, Meredith Crosby, Cecilia Devlin, Christopher Blick, Francesca Buffa, Ji-Liang Li, Borivoj Vojnovic, Ricardo Pires das Neves, Peter Glazer, Francisco Iborra, Mircea Ivan, Jiannis Ragoussis, Adrian L Harris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2859946?pdf=render

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http://europepmc.org/articles/PMC2859946?pdf=render

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