A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity

A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity

Summary: Hepatic lipid accumulation is a hallmark of type II diabetes (T2D) associated with hyperinsulinemia, insulin resistance, and hyperphagia. Hepatic synthesis of GABA, catalyzed by GABA-transaminase (GABA-T), is upregulated in obese mice. To assess the role of hepatic GABA production in obesit...

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Bibliographic Details
Main Authors: Caroline E. Geisler, Susma Ghimire, Stephanie M. Bruggink, Kendra E. Miller, Savanna N. Weninger, Jason M. Kronenfeld, Jun Yoshino, Samuel Klein, Frank A. Duca, Benjamin J. Renquist
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
obesity
NAFLD
hyperinsulinemia
insulin resistance
GABA
GABA transaminase
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472100677X

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http://www.sciencedirect.com/science/article/pii/S221112472100677X

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