FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy

FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy

Hepatic encephalopathy is a serious neurologic complication of acute and chronic liver diseases. We previously showed that aberrant bile acid signaling contributes to the development of hepatic encephalopathy via farnesoid X receptor (FXR)-mediated mechanisms in neurons. In the brain, a novel altern...

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Bibliographic Details
Main Authors: Matthew McMillin, Stephanie Grant, Gabriel Frampton, Anca D. Petrescu, Jessica Kain, Elaina Williams, Rebecca Haines, Lauren Canady, Sharon DeMorrow
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Cytochrome p450 46A1
Farnesoid X Receptor
Acute Liver Failure
Azoxymethane
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X18300456

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http://www.sciencedirect.com/science/article/pii/S2352345X18300456

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