Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer’s Disease

Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer’s Disease

Altered glucose metabolism has been implicated in the pathogenesis of Alzheimer’s disease (AD). Aerobic glycolysis from astrocytes is a critical metabolic pathway for brain energy metabolism. Disturbances of circadian rhythm have been associated with AD. While the role of circadian locomotor output...

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Bibliographic Details
Main Authors: Ik Dong Yoo, Min Woo Park, Hyeon Woo Cha, Sunmi Yoon, Napissara Boonpraman, Sun Shin Yi, Jong-Seok Moon
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
CLOCK
BMAL1
aerobic glycolysis
astrocytes
Alzheimer’s disease
Online Access:https://www.mdpi.com/1422-0067/21/21/7862

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https://www.mdpi.com/1422-0067/21/21/7862

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