Maternal-Fetal HLA Compatibility in Uncomplicated and Preeclamptic Naturally Conceived Pregnancies

Maternal-Fetal HLA Compatibility in Uncomplicated and Preeclamptic Naturally Conceived Pregnancies

IntroductionIn pregnancy, the mother and fetus differ in HLA antigens, and yet the maternal immune system generally tolerates the fetus. KIR receptors expressed by maternal uterine NK cells at the maternal-fetal interface directly interact with HLA-C on extravillous trophoblast cells for optimal pla...

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Bibliographic Details
Main Authors: Liseanne J. van ‘t Hof, Naomi Schotvanger, Geert W. Haasnoot, Carin van der Keur, Dave L. Roelen, Lisa E. E. L. O. Lashley, Frans H. J. Claas, Michael Eikmans, Marie-Louise P. van der Hoorn
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
human leukocyte antigen
HLA compatibility
pregnancy
preeclampsia
killer-cell Immunoglobin-like receptor
reproductive immunology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.673131/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.673131/full

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