Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

The Iroquois homeodomain transcription factor gene IRX3 is expressed in the developing nervous system, limb buds, and heart, and transcript levels specify obesity risk in humans. We now report a functional role for IRX3 in human acute leukemia. Although transcript levels are very low in normal human...

Full description

Bibliographic Details
Main Authors: Tim D.D. Somerville, Fabrizio Simeoni, John A. Chadwick, Emma L. Williams, Gary J. Spencer, Katalin Boros, Christopher Wirth, Eleni Tholouli, Richard J. Byers, Tim C.P. Somervaille
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
IRX3
HOXA9
acute myeloid leukemia
acute lymphoblastic leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319009

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717319009

Similar Items