Emergence of switch-like behavior in a large family of simple biochemical networks.

Bistability plays a central role in the gene regulatory networks (GRNs) controlling many essential biological functions, including cellular differentiation and cell cycle control. However, establishing the network topologies that can exhibit bistability remains a challenge, in part due to the exceed...

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Bibliographic Details
Main Authors: Dan Siegal-Gaskins, Maria Katherine Mejia-Guerra, Gregory D Smith, Erich Grotewold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21589886/?tool=EBI