Mechanical Loading Synergistically Increases Trabecular Bone Volume and Improves Mechanical Properties in the Mouse when BMP Signaling Is Specifically Ablated in Osteoblasts.

Mechanical Loading Synergistically Increases Trabecular Bone Volume and Improves Mechanical Properties in the Mouse when BMP Signaling Is Specifically Ablated in Osteoblasts.

Bone homeostasis is affected by several factors, particularly mechanical loading and growth factor signaling pathways. There is overwhelming evidence to validate the importance of these signaling pathways, however, whether these signals work synergistically or independently to contribute to proper b...

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Bibliographic Details
Main Authors: Ayaka Iura, Erin Gatenby McNerny, Yanshuai Zhang, Nobuhiro Kamiya, Margaret Tantillo, Michelle Lynch, David H Kohn, Yuji Mishina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4619208?pdf=render

Internet

http://europepmc.org/articles/PMC4619208?pdf=render

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