Triflic Anhydride Promoted Synthesis of Primary Amides and their Conversion into Nitriles

Triflic Anhydride Promoted Synthesis of Primary Amides and their Conversion into Nitriles

Abstract A facile, two-pot conversion of carboxylic acids into the corresponding nitriles has been developed using triflic anhydride as a promoter and aqueous NH4OH as a source of nitrogen. The methodology involves synthesis of primary amides from carboxylic acids as the key first step using triflic...

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Bibliographic Details
Main Authors: Anil Rana, Varun Kumar, Lata Tiwari, Anamika Thakur, Chhuttan Lal Meena, Dinesh Mahajan
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2018-04-01
Series:SynOpen
Subjects:
primary amides
nitriles
triflic anhydride
ammonium ­hydroxide
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1610154

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1610154

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